Tools for Bioinformatics -- The ImmunoGrid Simulator: How to Use It -- Improving Coiled-Coil Prediction with Evolutionary Information -- Intelligent Text Processing Techniques for Textual-Profile Gene Characterization -- SILACAnalyzer - A Tool for Differential Quantitation of Stable Isotope Derived Data -- Gene Expression Analysis -- Non-parametric MANOVA Methods for Detecting Differentially Expressed Genes in Real-Time RT-PCR Experiments -- In Silico Screening for Pathogenesis Related-2 Gene Candidates in Vigna Unguiculata Transcriptome -- Penalized Principal Component Analysis of Microarray Data -- An Information Theoretic Approach to Reverse Engineering of Regulatory Gene Networks from Time–Course Data -- New Perspectives in Bioinformatics -- On the Use of Temporal Formal Logic to Model Gene Regulatory Networks -- Predicting Protein-Protein Interactions with K-Nearest Neighbors Classification Algorithm -- Simulations of the EGFR - KRAS - MAPK Signalling Network in Colon Cancer. Virtual Mutations and Virtual Treatments with Inhibitors Have More Important Effects Than a 10 Times Range of Normal Parameters and Rates Fluctuations -- Special Session on “Using Game-Theoretical Tools in Bioinformatics” -- Basics of Game Theory for Bioinformatics -- Microarray Data Analysis via Weighted Indices and Weighted Majority Games -- Special Session on “Combining Bayesian and Machine Learning Approaches in Bioinformatics: State of Art and Future Perspectives” -- Combining Replicates and Nearby Species Data: A Bayesian Approach -- Multiple Sequence Alignment with Genetic Algorithms -- Special Session on “Data Clustering and Bioinformatics” (DCB 2009) -- Multiple Clustering Solutions Analysis through Least-Squares Consensus Algorithms -- Projection Based Clustering of Gene Expression Data -- Searching a Multivariate Partition Space Using MAX-SAT -- A Novel Approach for Biclustering Gene Expression Data Using Modular Singular Value Decomposition -- Special Session on “Intelligent Systems for Medical Decisions Support” (ISMDS 2009) -- Using Computational Intelligence to Develop Intelligent Clinical Decision Support Systems -- Different Methodologies for Patient Stratification Using Survival Data -- 3-D Mouse Brain Model Reconstruction from a Sequence of 2-D Slices in Application to Allen Brain Atlas -- A Proposed Knowledge Based Approach for Solving Proteomics Issues.

This book constitutes the thoroughly refereed post-conference proceedings of the Sixth International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2009, held in Genova, Italy, in October 2009. The revised 23 full papers presented were carefully reviewed and selected from 57 submissions. The main goal of the CIBB meetings is to provide a forum open to researchers from different disciplines to present and discuss problems concerning computational techniques in tools for bioinformatics, gene expression analysis and new perspectives in bioinformatics together with 4 special sessions on using game-theoretical tools in bioinformatics, combining Bayesian and machine learning approaches in bioinformatics: state of the art and future perspectives, data clustering and bioinformatics (DCB 2009) and on intelligent systems for medical decisions support (ISMDS 2009).