Oral Cancer Overview: The Significance of Metastasis and Surgical Management of the Neck -- The Role of Diagnostic Imaging in Identifying Cervical Metastases in Oral Cavity Cancer -- Sentinel Node Biopsy in Oral Cancer -- Prediction of Nodal Metastases from Genomic Analyses of the Primary Tumor -- The Role of High Throughput Molecular Analysis of Biofluids and Tumors in Patients with Oral Cancer -- Adjuvant Therapy for Patients with Oral Cavity Cancer -- Animal Models of Oral Cancer Metastasis -- TGF? Signaling in Head and Neck Cancer Development and Metastases -- Growth Factor Receptor Signaling and Metastasis of Oral Cancer -- Nuclear Transcription Factors and Signaling Pathways in Oral Cancer Metastasis -- Wnt/?-Catenin Signaling and Oral Cancer Metastasis -- Role of Tumor Stromal Interactions and Proteases in Oral Cancer Metastasis -- Chemokines and Their Receptors in Oral Cancer Metastasis -- Hypoxia, Angiogenesis, and Oral Cancer Metastasis -- Cancer Stem Cells and Oral Cavity Cancer Metastasis.

Squamous cell carcinoma of the oral cavity (SCCOC) is one of the most prevalent tumors of the head and neck region. Despite improvements in treatment, the survival of patients with SCCOC has not significantly improved over the past several decades. Most frequently, treatment failure takes the form of local and regional recurrences, but as disease control in these areas improves, SCCOC treatment failures more commonly occur as distant metastasis. This book summarizes the current status of investigations into SCCOC metastases and potential of these studies to positively impact clinical management of SCCOC in the future.