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Numerical Methods for the Life Scientist [electronic resource] : Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB / by Heino Prinz.

By: Prinz, Heino [author.].
Contributor(s): SpringerLink (Online service).
Material type: materialTypeLabelBookPublisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011Description: IX, 149p. 61 illus., 52 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783642208201.Subject(s): Life sciences | Bioinformatics | Life Sciences | Bioinformatics | Computational Biology/Bioinformatics | Mathematical and Computational BiologyDDC classification: 570.285 Online resources: Click here to access online
Contents:
Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches.  .
In: Springer eBooksSummary: Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
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Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches.  .

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

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