Phosphodiesterases as Drug Targets [electronic resource] / edited by Sharron H. Francis, Marco Conti, Miles D. Houslay.
By: Francis, Sharron H [editor.].
Contributor(s): Conti, Marco [editor.] | Houslay, Miles D [editor.] | SpringerLink (Online service).
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BookSeries: Handbook of Experimental Pharmacology: 204Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011Description: XVIII, 522 p. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783642179693.Subject(s): Medicine | Toxicology | Biochemistry | Enzymes | Post-translational modification of proteins | Cytology | Biomedicine | Pharmacology/Toxicology | Medicinal Chemistry | Protein Structure | Enzymology | Posttranslational Modification | Cell PhysiologyDDC classification: 615 Online resources: Click here to access online
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Springer eBooksSummary: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
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