Heart Rate and Rhythm [electronic resource] : Molecular Basis, Pharmacological Modulation and Clinical Implications / edited by Onkar N. Tripathi, Ursula Ravens, Michael C. Sanguinetti.
By: Tripathi, Onkar N [editor.].
Contributor(s): Ravens, Ursula [editor.] | Sanguinetti, Michael C [editor.] | SpringerLink (Online service).
Material type:
BookPublisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2011Description: XXII, 678p. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783642175756.Subject(s): Medicine | Human physiology | Toxicology | Cardiology | Biomedicine | Molecular Medicine | Human Physiology | Pharmacology/Toxicology | CardiologyDDC classification: 611.01816 Online resources: Click here to access online Normal Cardiac Rhythm and Pacemaker Activity -- Modeling of Rhythm in the Heart -- Cardiac Development and Anatomy -- Mechanisms of Acquired Arrhythmia -- Mechanisms of Inherited Arrhythmia -- Role of Specific Channels and Transporters in Arrhythmia -- Drugs and Cardiac Arrhythmia.
Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
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