The Eukaryotic Replisome: a Guide to Protein Structure and Function [electronic resource] / edited by Stuart MacNeill.
By: MacNeill, Stuart [editor.].
Contributor(s): SpringerLink (Online service).
Material type:
BookSeries: Subcellular Biochemistry: 62Publisher: Dordrecht : Springer Netherlands : Imprint: Springer, 2012Description: VIII, 345 p. 69 illus., 56 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9789400745728.Subject(s): Medicine | Oncology | Biochemistry | Nucleic acids | Biomedicine | Biomedicine general | Biochemistry, general | Protein Science | Protein Structure | Nucleic Acid Chemistry | Cancer ResearchDDC classification: 610 Online resources: Click here to access online
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Springer eBooksSummary: Successful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Inspired by recent exciting breakthroughs in protein structure determination and written by leading experts in the field, The Eukaryotic Replisome: a guide to protein structure and function takes the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosomal DNA replication, from replication origin recognition and the assembly of the pre-replicative complexes in G1 through to the final processing of Okazaki fragments at the end of S-phase. This extensively illustrated book is an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.
Successful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Inspired by recent exciting breakthroughs in protein structure determination and written by leading experts in the field, The Eukaryotic Replisome: a guide to protein structure and function takes the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosomal DNA replication, from replication origin recognition and the assembly of the pre-replicative complexes in G1 through to the final processing of Okazaki fragments at the end of S-phase. This extensively illustrated book is an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.
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