p53 in the Clinics (Record no. 95001)
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000 -LEADER | |
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fixed length control field | 03360nam a22004575i 4500 |
001 - CONTROL NUMBER | |
control field | 978-1-4614-3676-8 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | DE-He213 |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20140220082812.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 120829s2013 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
International Standard Book Number | 9781461436768 |
-- | 978-1-4614-3676-8 |
024 7# - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1007/978-1-4614-3676-8 |
Source of number or code | doi |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
Classification number | RC261-271 |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MJCL |
Source | bicssc |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MED062000 |
Source | bisacsh |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
Classification number | 614.5999 |
Edition number | 23 |
100 1# - MAIN ENTRY--PERSONAL NAME | |
Personal name | Hainaut, Pierre. |
Relator term | editor. |
245 10 - TITLE STATEMENT | |
Title | p53 in the Clinics |
Medium | [electronic resource] / |
Statement of responsibility, etc | edited by Pierre Hainaut, Magali Olivier, Klas G. Wiman. |
264 #1 - | |
-- | New York, NY : |
-- | Springer New York : |
-- | Imprint: Springer, |
-- | 2013. |
300 ## - PHYSICAL DESCRIPTION | |
Extent | X, 355 p. 45 illus., 30 illus. in color. |
Other physical details | online resource. |
336 ## - | |
-- | text |
-- | txt |
-- | rdacontent |
337 ## - | |
-- | computer |
-- | c |
-- | rdamedia |
338 ## - | |
-- | online resource |
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-- | rdacarrier |
347 ## - | |
-- | text file |
-- | |
-- | rda |
505 0# - FORMATTED CONTENTS NOTE | |
Formatted contents note | Foreword -- p53 activities and the hallmarks of cancer -- The inheritance of p53 -- p53: Guardian of the metabolome -- The p53 family and stem cell biology -- Mutant p53-driven tumorigenesis -- Humanized p53 mouse models -- p53 models for mammary carcinogenesis -- TP53 somatic mutations: Prognostic and predictive value in human cancers -- Assessing TP53 status in human tumors - lessons from breast cancer -- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome -- TP53 gene therapy -- Upstream targets in the p53 pathway -- p53-reactivating molecules as research tools and anti-cancer drugs -- Restoring mutant p53 activity -- p53-immunotherapy of cancer -- Designing p53 trials: a surgical oncologist view -- p53 in the clinic: a pathologist view -- p53 in genetic counseling -- Index. |
520 ## - SUMMARY, ETC. | |
Summary, etc | With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on cancer management and therapy. This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of 25 Years of p53 Research and condensates in a series of authoritative chapters the considerable progress on the applications of p53 into the clinics and the substantial advances on diseases caused by inheritance of p53 defects, on somatic p53 mutations as biomarkers in molecular pathology, on progress in gene therapy and on developments of innovative drugs and clinical trials. This volume will appeal to a wide audience of students and professionals in basic and clinical cancer research and treatment, and will highlight the exciting “next steps” in p53 research and applications. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Medicine. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Oncology. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Toxicology. |
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Biomedicine. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Cancer Research. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Pharmacology/Toxicology. |
700 1# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Olivier, Magali. |
Relator term | editor. |
700 1# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Wiman, Klas G. |
Relator term | editor. |
710 2# - ADDED ENTRY--CORPORATE NAME | |
Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY | |
Title | Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
Display text | Printed edition: |
International Standard Book Number | 9781461436751 |
856 40 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | http://dx.doi.org/10.1007/978-1-4614-3676-8 |
912 ## - | |
-- | ZDB-2-SBL |
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