Cancer Genome and Tumor Microenvironment (Record no. 110240)
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000 -LEADER | |
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fixed length control field | 04172nam a22004455i 4500 |
001 - CONTROL NUMBER | |
control field | 978-1-4419-0711-0 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | DE-He213 |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20140220084503.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 110414s2010 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
International Standard Book Number | 9781441907110 |
-- | 978-1-4419-0711-0 |
024 7# - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1007/978-1-4419-0711-0 |
Source of number or code | doi |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
Classification number | RC261-271 |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MJCL |
Source | bicssc |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MED062000 |
Source | bisacsh |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
Classification number | 614.5999 |
Edition number | 23 |
100 1# - MAIN ENTRY--PERSONAL NAME | |
Personal name | Thomas-Tikhonenko, Andrei. |
Relator term | editor. |
245 10 - TITLE STATEMENT | |
Title | Cancer Genome and Tumor Microenvironment |
Medium | [electronic resource] / |
Statement of responsibility, etc | edited by Andrei Thomas-Tikhonenko. |
264 #1 - | |
-- | New York, NY : |
-- | Springer New York, |
-- | 2010. |
300 ## - PHYSICAL DESCRIPTION | |
Extent | IX, 480p. 58 illus., 29 illus. in color. |
Other physical details | online resource. |
336 ## - | |
-- | text |
-- | txt |
-- | rdacontent |
337 ## - | |
-- | computer |
-- | c |
-- | rdamedia |
338 ## - | |
-- | online resource |
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-- | rdacarrier |
347 ## - | |
-- | text file |
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-- | rda |
490 1# - SERIES STATEMENT | |
Series statement | Cancer Genetics |
505 0# - FORMATTED CONTENTS NOTE | |
Formatted contents note | Opening Remarks -- Hardwiring Tumor Progression -- Breaking Away: Epithelial-Mesenchymal Transition -- PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition -- Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells -- Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment -- Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression -- Coming up for Air: Hypoxia and Angiogenesis -- von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization -- RAS Oncogenes and Tumor-Vascular Interface -- Myc and Control of Tumor Neovascularization -- p53 and Angiogenesis -- Ink4a Locus: Beyond Cell Cycle -- Gaining New Ground: Metastasis and Stromal Cell Interactions -- Nm23 as a Metastasis Inhibitor -- HGF/c-MET Signaling in Advanced Cancers -- Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis -- Stromal Cells and Tumor Milieu: PDGF et al. -- TGF-? Signaling Alterations in Neoplastic and Stromal Cells -- Getting Attention: Immune Recognition and Inflammation -- Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers -- Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis -- Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment -- Putting It All Together -- Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interface -- Cooperation and Cancer. |
520 ## - SUMMARY, ETC. | |
Summary, etc | Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Medicine. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Oncology. |
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Biomedicine. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Cancer Research. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Oncology. |
710 2# - ADDED ENTRY--CORPORATE NAME | |
Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY | |
Title | Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
Display text | Printed edition: |
International Standard Book Number | 9781441907103 |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
Uniform title | Cancer Genetics |
856 40 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | http://dx.doi.org/10.1007/978-1-4419-0711-0 |
912 ## - | |
-- | ZDB-2-SBL |
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