Molecular Determinants of Radiation Response (Record no. 105921)
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000 -LEADER | |
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fixed length control field | 03965nam a22004815i 4500 |
001 - CONTROL NUMBER | |
control field | 978-1-4419-8044-1 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | DE-He213 |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20140220083726.0 |
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
fixed length control field | cr nn 008mamaa |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 110322s2011 xxu| s |||| 0|eng d |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
International Standard Book Number | 9781441980441 |
-- | 978-1-4419-8044-1 |
024 7# - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1007/978-1-4419-8044-1 |
Source of number or code | doi |
050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
Classification number | RC261-271 |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MJCL |
Source | bicssc |
072 #7 - SUBJECT CATEGORY CODE | |
Subject category code | MED062000 |
Source | bisacsh |
082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
Classification number | 614.5999 |
Edition number | 23 |
100 1# - MAIN ENTRY--PERSONAL NAME | |
Personal name | DeWeese, Theodore L. |
Relator term | editor. |
245 10 - TITLE STATEMENT | |
Title | Molecular Determinants of Radiation Response |
Medium | [electronic resource] / |
Statement of responsibility, etc | edited by Theodore L. DeWeese, Marikki Laiho. |
250 ## - EDITION STATEMENT | |
Edition statement | 1. |
264 #1 - | |
-- | New York, NY : |
-- | Springer New York, |
-- | 2011. |
300 ## - PHYSICAL DESCRIPTION | |
Extent | XVI, 276 p. |
Other physical details | online resource. |
336 ## - | |
-- | text |
-- | txt |
-- | rdacontent |
337 ## - | |
-- | computer |
-- | c |
-- | rdamedia |
338 ## - | |
-- | online resource |
-- | cr |
-- | rdacarrier |
347 ## - | |
-- | text file |
-- | |
-- | rda |
490 1# - SERIES STATEMENT | |
Series statement | Current Cancer Research |
505 0# - FORMATTED CONTENTS NOTE | |
Formatted contents note | Molecular Basis of the DNA Damage Responses -- ATM signaling and DNA Damage -- H2AX in DNA Damage Response -- Dynamic Imaging of DNA Damage Foci -- DNA Damage Signaling Downstream of ATM -- Checkpoint Control and Radiation -- Chromatin Responses to DNA Damage.-DNA Damage Response and Senescence -- C. elegans and DNA Damage -- Modulation of Radiation Responses – Opportunities for Therapeutic Exploitation -- The Stem Cell and Radiation -- Role of the Cell Membrane in Signaling Radiation Injury -- Hypoxia and Modulation of Cellular Radiation Response -- Role of PARP and PARP Inhibition in Cellular Response to Radiation -- Anti-angiogenic Therapies and Radiation Responses -- Gene Therapy and Radiation -- Radiation-mediated Molecular Targeting -- EGFR Signaling and Radiation -- Heat and Heat Shock Proteins Modulation of Radiation Response -- Radiation-induced Immune Modulation. |
520 ## - SUMMARY, ETC. | |
Summary, etc | The DNA of mammalian cells is constantly under assault from both endogenous and exogenous sources. Ionizing radiation is one of the most important sources of genomic injury because of its ability to inflict substantial cellular damage that is both therapeutic as well as mutagenic. Mammalian cells have evolved an impressive array of DNA damage response mechanisms that are called upon to respond to and repair radiation-induced DNA injury that allow cells to survive with DNA fidelity intact. Contemporary oncologic research and patient management demand a thorough understanding of these DNA damage response processes as well as some of the important environmental conditions like hypoxia in which cells exist such that strategies that subvert these survival processes can be considered and exploited for therapeutic gain. Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. The authors have done a wonderful job in providing meaningful reviews, with appropriate detail and scope for both the well informed reader as well as the novice looking for new information. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Medicine. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Oncology. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Toxicology. |
650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Biomedicine. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Cancer Research. |
650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name as entry element | Pharmacology/Toxicology. |
700 1# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Laiho, Marikki. |
Relator term | editor. |
710 2# - ADDED ENTRY--CORPORATE NAME | |
Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
773 0# - HOST ITEM ENTRY | |
Title | Springer eBooks |
776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
Display text | Printed edition: |
International Standard Book Number | 9781441980434 |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
Uniform title | Current Cancer Research |
856 40 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | http://dx.doi.org/10.1007/978-1-4419-8044-1 |
912 ## - | |
-- | ZDB-2-SME |
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