Folding for the Synapse (Record no. 105680)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04703nam a22005055i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-4419-7061-9 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220083722.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 130531s2011 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781441970619 |
| -- | 978-1-4419-7061-9 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-4419-7061-9 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC321-580 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PSAN |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED057000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612.8 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Wyttenbach, Andreas. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | Folding for the Synapse |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Andreas Wyttenbach, Vincent O'Connor. |
| 264 #1 - | |
| -- | Boston, MA : |
| -- | Springer US : |
| -- | Imprint: Springer, |
| -- | 2011. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | VIII, 318p. 57 illus., 37 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Introduction,- Protein Folding and Molecular Chaperones -- Transport of Proteins and Vesicles to the Synapse -- Protein Synthesis, Folding and Degradation in the Synaptic Compartment -- Synaptic Protein Interactions/Reguatlion by Molecular Chaperones -- Folding/Misfolding and Synaptic Dysfunction During Chronic Neurodegeration. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Folding for the Synapse addresses the current view on how protein folding/misfolding and its regulation by molecular chaperones contribute to synapse function and dysfunction. Molecular chaperones control de novo protein folding. However, there is increasing awareness that chaperones physiologically function to regulate protein-protein interaction cascades. This book will introduce the concept of folding machineries and also give examples of the biological relevance of further chaperone modality. Chaperones prevent misfolded proteins from accumulating into toxic intra-or extracellular aggregates in Alzheimer’s, Parkinson’s, Huntington’s, prion, and motor neuron diseases (proteinopathies). The various disease-defining protein aggregates in these proteinopathies are indicative of overstretched chaperone-and altered protein degradation systems. The consequence of this for neuronal function is discussed in several contributing chapters. Synapses regulate cell-to-cell communication in the nervous system as relatively discrete compartments that are dysfunctional during proteinopathies. Due to their partial autarky, synapses have evolved intrinsic protein folding and homeostatic capabilities that are discussed in the book. The book servesced undergraduates, graduate students and (clinical) neuroscientists who want to develop an understanding of protein folding in health and disease. About the Editors: Dr. Andreas Wyttenbach holds a lectureship in Neuroscience at the University of Southampton (UK). After graduating in Biology at the University of Basel (Switzerland) he completed a PhD in Genetics and Evolution (University of Lausanne, Switzerland). During his postdoctoral research in the Departments of Medical Genetics and Biochemistry at the University of Cambridge (UK), he became inspired by the question of how protein misfolding in the CNS causes neuronal death, associated with neurological diseases. His current research concentrates on understanding how protein aggregation damages cells, with the motivation to provide a basis for therapeutic approaches that could prevent neurodegeneration. Dr. Vincent O’Connor holds a readership at the University of Southampton. After his undergraduate studies in Physiology and Biochemistry at Reading University (UK), he trained at University College London (UK), graduating with a PhD in Neurochemistry. His postdoctoral time was spent at the Max Planck Institute for Brain Research (Frankfurt, Germany) and the National Institute for Medical Research (London, UK) investigating mechanisms of neurotransmitter release and synaptic plasticity. His current efforts focus on translating the knowledge of basic synaptic mechanisms into understanding CNS disease processes and the concept of “synaptopathies” |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurosciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cytology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurobiology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurosciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Molecular Medicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurobiology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cell Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry, general. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | O'Connor, Vincent. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9781441970602 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-1-4419-7061-9 |
| 912 ## - | |
| -- | ZDB-2-SBL |
No items available.