Phosphoinositides and Disease (Record no. 104836)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04167nam a22004215i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-94-007-5025-8 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220083347.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 121026s2012 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9789400750258 |
| -- | 978-94-007-5025-8 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-94-007-5025-8 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | R-RZ |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED000000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | FALASCA, MARCO. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | Phosphoinositides and Disease |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by MARCO FALASCA. |
| 264 #1 - | |
| -- | Dordrecht : |
| -- | Springer Netherlands : |
| -- | Imprint: Springer, |
| -- | 2012. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | VI, 318 p. 28 illus., 13 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Current Topics in Microbiology and Immunology, |
| International Standard Serial Number | 0070-217X ; |
| Volume number/sequential designation | 362 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Table of contents -- An introduction to Phosphoinositides, Tania Maffucci -- Phosphoinositides and Cardiovascular Diseases, Emilio Hirsch -- Phosphoinositides in Insulin Action and Diabetes, Alan Saltiel -- Phosphoinositides in neuroexocytosis and neuronal diseases, Frederic Meunier -- Effects of Phosphoinositides and their derivatives on Membrane Morphology and function, Banafshe Larijani -- Molecular analysis of protein-phosphoinositide interactions, Tatiana Kutateladze -- PIKfyve and its lipid products in health and in sickness, Assia Shisheva -- Class I phosphoinositide 3-kinases in normal and pathologic haematopoietic cells, Bernard Payrastre -- The diverse functions of Phosphatidylinositol Transfer proteins, Shamshad Cockcroft -- Myotubularin phosphoinositide phosphatases in human diseases, Jocelyn Laporte -- Nuclear PI-PLC β1 and Myelodysplastic Syndromes: from bench to clinics, Lucio Cocco -- Inositol polyphosphate phosphatases in human disease, Christina Mitchell -- Index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine general. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9789400750241 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Current Topics in Microbiology and Immunology, |
| -- | 0070-217X ; |
| Volume number/sequential designation | 362 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-94-007-5025-8 |
| 912 ## - | |
| -- | ZDB-2-SBL |
No items available.